Lek ICD10 ICD10_EN SYMBOL Variant_ID TIER n_collapsed collapsed_genes internal_pleiotropy OT_gene_disease_score latent_pgx_score latent_pgx_candidate latent_confidence expert_downweight_reason kmeans_cluster gmm_cluster lca_cluster hdbscan_cluster simvastatin I831 Varicose veins of lower extr. with inflammation ABHD14B 3-51964935-G-A 4 7 -;ABHD14B;DUSP7;PCBP4;RPL29;RRP9 1 0.0 0.19374308011002656 0 HIGH replicated comorbidity: statins protective for varicose in large studies; age co-occurrence with the CV indication C1 C3 C5 C1 simvastatin I831 Varicose veins of lower extr. with inflammation DOCK3 3-51070309-T-C 4 1 DOCK3 1 0.03788193510518193 0.19101989729513966 0 HIGH replicated comorbidity: statins protective for varicose in large studies; age co-occurrence with the CV indication C1 C3 C5 C3 simvastatin I831 Varicose veins of lower extr. with inflammation CHRM2 7-137009844-C-T 2 2 CHRM2;ENSG00000234352 1 0.0 0.19638950614739586 0 HIGH replicated comorbidity: statins protective for varicose in large studies; age co-occurrence with the CV indication C1 C3 C5 C3 ramipril H931 Tinnitus AGTPBP1 9-85557777-A-G 4 1 AGTPBP1 1 0.0 0.557923121388643 0 MED repl-underpowered C1 C3 C4 C1 ramipril H931 Tinnitus RAB9A X-13687533-T-A 4 1 RAB9A 1 0.0 0.5569153432931004 1 HIGH replicated C1 C3 C5 C2 citalopram K317 Polyp of stomach and duodenum N4BP3 5-178113919-G-A 4 1 N4BP3 1 0.0 0.6498553798692331 1 HIGH replicated C1 C3 C5 C1 citalopram K317 Polyp of stomach and duodenum NFIB 9-14115218-G-C 2 1 NFIB 1 0.0022174791281082107 0.6769535580393076 0 HIGH replicated C1 C3 C5 C1 atenolol R634 Abnormal weight loss PPP1R12B 1-202410290-A-G 4 1 PPP1R12B 1 0.0 0.6211495665634291 0 HIGH replicated C1 C3 C5 C1 citalopram A099 Gastroenteritis ADAM22 7-88134075-A-G 4 1 ADAM22 1 0.0 0.6167277005209721 1 HIGH replicated C1 C3 C5 C3 fluoxetine R55 Syncope and collapse CDH22 20-46262088-G-A 4 1 CDH22 1 0.0 0.5873893559907976 1 HIGH replicated C1 C3 C5 C1 ramipril A099 Gastroenteritis PTPRD 9-10425290-A-G 4 1 PTPRD 1 0.0 0.5937983517782971 1 HIGH replicated C1 C3 C5 C3 ramipril R35 Polyuria UBR5 8-102263442-A-C 4 1 UBR5 1 0.0 0.6078853059163769 1 HIGH replicated C1 C3 C5 C1 amlodipine E86 Volume depletion XPO6 16-28093273-T-C 4 1 XPO6 1 0.0 0.6025680277937382 1 HIGH replicated C1 C3 C5 C3 diazepam J449 COPD, unspecified PDE1C 7-32069723-A-C 4 2 PDE1C 1 0.0 0.6159701002211541 1 HIGH replicated C1 C3 C5 C3 diazepam J449 COPD, unspecified CXCL13 4-77601109-C-T 2 1 CXCL13 1 0.0 0.6207676126328626 1 HIGH replicated C1 C3 C5 C1 lisinopril R739 Hyperglycaemia RYR2 1-237808852-T-C 4 8 RYR2 1 0.0 0.48238893151197787 1 MED repl-underpowered C1 C3 C5 C1 citalopram M819 Osteoporosis, unspecified DLEU1 13-50464150-A-T 4 1 DLEU1 1 0.0 0.5341713559457654 1 HIGH replicated C1 C3 C5 C3 lisinopril J449 COPD P4HA3 P4HA3_mpc 3 1 P4HA3 1 0.0 0.5719264125592411 1 HIGH replicated C2 C4 C3 C1 bisoprolol E872 Acidosis PAPPA2 1-176461865-T-C 3 1 PAPPA2 1 0.0 0.5433379167933234 1 MED repl-underpowered C1 C2 C5 C2 bisoprolol E872 Acidosis MYSM1 1-58676108-G-A 3 1 MYSM1 1 0.0 0.5895045586357365 1 MED repl-underpowered C1 C2 C5 C2 bisoprolol R410 Disorientation SPRTN SPRTN_mpc 3 1 SPRTN 4 0.0 0.3756847405695898 1 MED repl-underpowered C2 C4 C3 C1 atorvastatin E162 Hypoglycaemia, unspecified TRIM11 TRIM11_mpc 3 1 TRIM11 1 0.0 0.573074948316493 1 HIGH replicated C2 C4 C3 C1 ramipril R410 Disorientation, unspecified GJB6 13-20231113-C-T 3 1 GJB6 1 0.0 0.5377663003784054 1 MED repl-underpowered C1 C2 C5 C1 zopiclone K297 Gastritis, unspecified POU2AF2 11-111249271-G-A 3 1 POU2AF2 1 0.0 0.5447989361301419 1 MED repl-underpowered C1 C2 C4 C2 atenolol K760 Fatty liver NEC CDKL5 X-18600498-G-A 3 1 CDKL5 1 0.0 0.5735819062212616 1 MED repl-underpowered C1 C2 C5 C2 atenolol K760 Fatty liver NEC CNBD1 8-87498680-C-T 2 1 CNBD1 1 0.1847899273423509 0.5983127207467079 0 MED repl-underpowered C1 C2 C5 C1 furosemide R040 Epistaxis TBC1D4 13-75352809-G-T 3 1 TBC1D4 1 0.0 0.5536536782574297 1 MED repl-underpowered C1 C3 C5 C1 tramadol R33 Retention of urine TBPL1 TBPL1_mpc 3 1 TBPL1 1 0.0 0.5772652081528533 1 MED repl-underpowered C2 C4 C3 C1 furosemide K922 GI haemorrhage, unspecified DNM3 1-172136588-A-G 3 1 DNM3 1 0.0 0.5157812993327375 1 MED repl-underpowered C1 C2 C4 C2 simvastatin J310 Chronic rhinitis DENND1C DENND1C_mpc 3 1 DENND1C 1 0.0 0.5103385612557024 1 HIGH replicated C2 C4 C3 C1 gabapentin R42 Dizziness and giddiness ELOVL5 6-53274512-T-A 3 2 ELOVL5;ENSG00000296254 1 0.0 0.38083538445642723 1 MED repl-underpowered C1 C2 C4 C1 amlodipine I959 Hypotension, unspecified TWIST1 7-19099338-G-A 3 1 TWIST1 1 0.0942948378432198 0.5545168707066939 1 MED repl-underpowered C1 C2 C4 C2 simvastatin R600 Localised oedema SPRTN SPRTN_mpc 3 1 SPRTN 4 0.0 0.3829007816348767 1 MED repl-underpowered C2 C4 C3 C1 simvastatin R600 Localised oedema chr2:97000001-97100001_cnv_region_up chr2:97000001-97100001_cnv_region_up 2 1 chr2:97000001-97100001_cnv_region_up 1 0.0 0.5100500335136354 1 MED repl-underpowered C1 C3 C5 C1 furosemide E871 Hypo-osmolality and hyponatraemia SMAD3 15-67164634-A-G 3 1 SMAD3 1 0.0 0.6207989846195908 1 HIGH replicated C1 C2 C5 C1 atorvastatin K30 Dyspepsia SEL1L3 4-25747317-C-T 3 1 SEL1L3 1 0.0 0.5762856541791708 1 HIGH replicated C1 C1 C4 C4 furosemide E162 Hypoglycaemia, unspecified LEKR1 3-156980109-A-G 3 1 LEKR1 1 0.0 0.4918152391272602 1 MED repl-underpowered C1 C2 C5 C1 citalopram H919 Hearing loss, unspecified HK1 10-69276684-A-G 3 1 HK1 1 0.0014783194187388072 0.34434530049037937 0 HIGH replicated C1 C1 C4 C4 amlodipine N309 Cystitis, unspecified PTPN12 PTPN12_mpc 3 1 PTPN12 2 0.0 0.3958653854445625 1 MED repl-underpowered C2 C4 C3 C1 simvastatin K579 Diverticular disease SEC14L1 17-77212716-T-C 3 1 SEC14L1 1 0.0 0.32744568897548704 0 HIGH replicated C1 C1 C4 C1 simvastatin R13 Dysphagia ABTB3 12-107507573-C-T 3 1 ABTB3 1 0.0 0.534950782775765 1 HIGH replicated C1 C1 C4 C1 simvastatin N951 Menopausal state SPRTN SPRTN_mpc 3 1 SPRTN 4 0.0 0.23764545666627485 0 HIGH replicated C2 C4 C3 C1 amlodipine N390 Urinary tract infection DPP7 DPP7_lof 3 1 DPP7 1 0.05504175555489434 0.5146415023245791 1 HIGH replicated C1 C1 C4 C4 clopidogrel K30 Dyspepsia SLC8A1 2-40187733-G-A 3 1 SLC8A1 4 0.0 0.44120263586274283 1 HIGH replicated C1 C1 C4 C1 simvastatin N40 Enlarged prostate SPRED1 SPRED1_mpc 3 1 SPRED1 1 0.01270944055832391 0.3088659808887783 0 HIGH replicated C2 C4 C3 C1 tramadol A099 Gastroenteritis CPED1 7-121161842-G-A 3 1 CPED1 1 0.0 0.5226976560340548 0 HIGH replicated C1 C1 C4 C4 amlodipine E669 Obesity, unspecified LRCOL1 LRCOL1_lof 3 1 LRCOL1 1 0.0 0.480860095967676 1 MED repl-underpowered C1 C1 C4 C1 bisoprolol G439 Migraine, unspecified ATP8A2 13-25972430-G-A 3 1 ATP8A2 1 0.0022174791281082107 0.43867017635839656 1 HIGH replicated C1 C1 C4 C1 furosemide K30 Dyspepsia UQCC1 20-35390799-C-T 3 1 UQCC1 1 0.0 0.5897072695653935 1 HIGH replicated C1 C1 C4 C4 gabapentin K625 Haemorrhage of anus and rectum CRISPLD2 16-84915773-G-A 3 1 CRISPLD2 1 0.0 0.5230755287705411 1 HIGH replicated C1 C1 C4 C1 tramadol N309 Cystitis, unspecified TPRA1 TPRA1_mpc 3 1 TPRA1 1 0.0 0.508091186953457 1 HIGH replicated C2 C4 C3 C1 atorvastatin H931 Tinnitus RABGAP1L 1-174228581-A-G 3 3 RABGAP1L 1 0.0 0.49900845297141466 1 MED repl-underpowered C1 C1 C4 C4 clopidogrel R13 Dysphagia SLC30A9 4-42078960-T-G 3 2 SLC30A9 1 0.0 0.5490707866071464 1 HIGH replicated C1 C1 C4 C1 losartan N309 Cystitis, unspecified DMD X-32609243-G-A 3 1 DMD 1 0.0 0.41892439521371544 1 MED repl-underpowered C1 C1 C4 C1 furosemide I219 Acute myocardial infarction PRKG1 10-51675580-C-T 3 3 PRKG1 1 0.2548054359704634 0.539552546534571 1 HIGH replicated C1 C1 C4 C4 propranolol R51 Headache SLC9A2 SLC9A2_mpc 3 1 SLC9A2 1 0.0 0.5038649399236415 1 HIGH replicated C2 C4 C3 C1 simvastatin M706 Trochanteric bursitis - 6-156588192-C-T 3 1 - 1 0.0 0.5588454015335526 0 HIGH replicated C1 C3 C5 C1 simvastatin M706 Trochanteric bursitis - 8-98358868-C-T 3 1 - 1 0.0 0.5410439780411087 1 HIGH replicated C1 C3 C5 C1 simvastatin R80 Isolated proteinuria NLGN1 3-173819694-A-G 3 1 NLGN1 1 0.0 0.17948628872487488 0 HIGH replicated C1 C6 C4 C1 gabapentin I251 Atherosclerotic heart disease CPNE4 3-131654696-C-T 3 1 CPNE4 1 0.18239955165716296 0.557530322412789 1 HIGH replicated C1 C1 C4 C4 amlodipine R529 Pain, unspecified NPAS3 14-33568506-A-G 3 1 NPAS3 1 0.03817108592891665 0.4893535920718921 1 MED repl-underpowered C1 C1 C4 C1 amlodipine R529 Pain, unspecified LINC01019 5-3525655-C-T 2 1 LINC01019 1 0.0 0.4907699269532331 1 MED repl-underpowered C1 C1 C4 C1 lisinopril R600 Localised oedema ENSG00000232389 6-70607996-A-G 3 1 ENSG00000232389 1 0.0 0.6652921267521137 1 HIGH replicated C1 C3 C5 C1 lisinopril R600 Localised oedema ENSG00000287526 19-34040164-G-A 3 1 ENSG00000287526 1 0.0 0.6653987184046395 1 HIGH replicated C1 C3 C5 C1 ramipril J90 Pleural effusion ENSG00000293906 13-28735638-G-A 3 1 ENSG00000293906 1 0.0 0.5738752573903306 1 HIGH replicated C1 C3 C5 C1 tramadol N328 Other specified disorders of bladder - 10-76769795-G-T 3 1 - 1 0.0 0.592101686315876 1 HIGH replicated C1 C3 C5 C1 zopiclone R074 Chest pain, unspecified - 10-91124837-C-T 3 1 - 1 0.0 0.6507933723778607 1 HIGH replicated C1 C3 C5 C1 atorvastatin H919 Hearing loss A2ML1 12-8831374-C-G 3 1 A2ML1 1 0.0 0.29541109309810665 0 MED repl-underpowered C1 C1 C4 C1 atorvastatin R529 Pain, unspecified RBMS1 2-160292652-G-A 3 1 RBMS1 1 0.0 0.3939165015728156 1 MED repl-underpowered C1 C1 C4 C1 amitriptyline G470 Insomnia - X-4781444-T-G 3 1 - 2 0.0 0.26443101864250135 1 HIGH replicated C1 C3 C5 C1 amlodipine R410 Disorientation ENSG00000294396 11-44992783-A-G 3 1 ENSG00000294396 2 0.0 0.5280932148196688 1 HIGH replicated C1 C3 C5 C1 atorvastatin G473 Sleep apnoea ENSG00000298364 2-78427035-T-C 3 2 ENSG00000227088;ENSG00000298364 2 0.0 0.4493660504831707 1 MED repl-underpowered C1 C3 C5 C1 ramipril B379 Candidiasis, unspecified WWC3 X-10077376-T-C 3 1 WWC3 1 0.0 0.31555215003948023 0 HIGH replicated C1 C1 C4 C1 ramipril B379 Candidiasis, unspecified ENSG00000287409 7-10083001-G-A 2 1 ENSG00000287409 1 0.0 0.3236202120597578 0 HIGH replicated C1 C1 C4 C4 lisinopril N309 Cystitis, unspecified ENSG00000285679 X-8312268-A-G 3 1 ENSG00000285679 1 0.0 0.5107542231362497 1 MED repl-underpowered C1 C3 C4 C2 ramipril I802 Phlebitis and thrombophlebitis RPL32P14 5-19038101-T-C 3 1 RPL32P14 1 0.0 0.5567224963316043 1 HIGH replicated C1 C1 C4 C4 amlodipine T810 Haemorrhage complicating procedure PARP6 PARP6_mpc 3 1 PARP6 1 0.0 0.5021070177292994 0 MED repl-underpowered C2 C4 C3 C1 atenolol M549 Dorsalgia, unspecified ENSG00000288545 18-45707749-T-A 3 1 ENSG00000288545 1 0.0 0.6148255848337453 1 HIGH replicated C1 C3 C5 C1 atenolol M549 Dorsalgia, unspecified LINC02934 2-65932155-T-C 2 2 LINC02934 2 0.0 0.46133721887681717 0 MED repl-underpowered C1 C2 C4 C1 lisinopril E871 Hypo-osmolality and hyponatraemia ENSG00000309049 8-97427479-C-T 3 1 ENSG00000309049 1 0.0 0.5620297491183238 1 MED repl-underpowered C1 C2 C4 C1 simvastatin Z980 Intestinal bypass/anastomosis status RNF167 RNF167_mpc 3 1 RNF167 1 0.0 0.350134988301268 0 HIGH replicated C2 C4 C3 C1 simvastatin H353 Degeneration of macula ENSG00000232153 2-34757937-C-T 3 1 ENSG00000232153 1 0.0 0.5850507630070673 0 HIGH replicated C1 C3 C5 C1 tramadol E785 Hyperlipidaemia - 13-68503449-C-T 3 1 - 1 0.0 0.5634222298371877 1 HIGH replicated C1 C3 C5 C3 citalopram Z966 Presence of orthopedic joint implant TP63 3-189833228-G-A 3 1 TP63 1 0.0 0.34269228945394636 0 MED repl-underpowered C1 C1 C4 C1 amitriptyline M069 Rheumatoid arthritis, unspecified - 7-82561437-T-C 3 1 - 1 0.0 0.5280637743636581 1 HIGH replicated C1 C3 C5 C1 atenolol R53 Malaise and fatigue GPR37 7-124766405-G-A 3 3 GPR37;POT1 1 0.0 0.33140148876031317 1 MED repl-underpowered C1 C1 C4 C1 ramipril D509 Iron deficiency anaemia ENSG00000266906 19-27981026-T-C 3 1 ENSG00000266906 1 0.0 0.5798478568635197 1 HIGH replicated C1 C3 C5 C3 ramipril C787 Secondary malignant neoplasm of liver TRERNA1 20-50041241-G-A 3 1 TRERNA1 1 0.050810009947791744 0.3411498139843397 0 HIGH replicated C1 C1 C4 C1 furosemide J441 COPD with acute exacerbation ENSG00000289368 6-23533888-C-T 3 1 ENSG00000289368 1 0.0 0.4892650384192217 1 HIGH replicated C1 C3 C5 C1 simvastatin G309 Alzheimer disease, unspecified APOC1 19-44919689-A-G 1 5 APOC1;APOE;NECTIN2 15 0.30102114337283636 0.0854586813299675 0 HIGH replicated C3 C5 C1 C1 atenolol R030 Elevated BP reading, without diagnosis of HT SATB2 2-199394154-T-C 1 1 SATB2 1 0.0036957985468470188 0.5623347144075908 1 HIGH replicated C1 C3 C5 C1 atenolol R030 Elevated BP reading, without diagnosis of HT RPL13P 6-28864488-G-A 1 1 RPL13P 1 0.0 0.5670328014317839 1 HIGH replicated C1 C3 C5 C1 atenolol R030 Elevated BP reading, without diagnosis of HT - 21-20375273-A-T 1 1 - 1 0.0 0.5873390825604764 1 HIGH replicated C1 C3 C5 C1 atorvastatin K760 Fatty liver NEC FBLIM1 1-15757809-G-A 1 1 FBLIM1 1 0.0022174791281082107 0.5152038367201383 1 MED repl-underpowered C1 C2 C4 C1 amitriptyline H931 Tinnitus OGT X-71569459-G-A 1 1 OGT 1 0.0 0.4831383144175727 1 MED repl-underpowered C1 C2 C4 C2 amitriptyline H931 Tinnitus LINC01449 7-41114148-A-G 1 2 ENSG00000302868;LINC01449 1 0.0 0.49964944739165185 1 MED repl-underpowered C1 C2 C5 C1 amitriptyline H931 Tinnitus ENSG00000304974 14-43334081-A-G 1 2 ENSG00000304974 1 0.0 0.47052787167444077 1 MED repl-underpowered C1 C2 C4 C1 amitriptyline H931 Tinnitus F11-AS1 4-186367191-A-C 1 1 F11-AS1 1 0.0 0.5337224880203201 0 HIGH replicated C1 C3 C5 C1 fluoxetine N951 Menopausal state TERF2IP TERF2IP_mpc 1 1 TERF2IP 1 0.028827228665406743 0.13953572993948832 0 HIGH replicated indication: SSRIs used for menopausal vasomotor symptoms (off-label) C2 C4 C3 C1 simvastatin E785 Hyperlipidaemia, unspecified EXOSC8 EXOSC8_lof 1 1 EXOSC8 1 0.0 0.47145401032290846 0 HIGH replicated C1 C3 C5 C1 amitriptyline G500 Trigeminal neuralgia NPAS3 14-33500816-A-G 1 1 NPAS3 1 0.0 0.3931959786677979 1 MED repl-underpowered C1 C2 C5 C1 amitriptyline M797 Fibromyalgia GRIA1 5-153805544-A-G 1 18 -;GRIA1;LINC01861;MFAP3 1 0.0014783194187388072 0.4783396391932659 0 HIGH replicated C1 C3 C5 C1 amitriptyline M797 Fibromyalgia GPC4 X-133395658-G-A 1 2 GPC4 1 0.0 0.498360419518989 0 HIGH replicated C1 C3 C5 C1 amitriptyline M797 Fibromyalgia GRIA1 5-153797151-C-T 1 20 GRIA1 1 0.0014783194187388072 0.47877983150978953 0 HIGH replicated C1 C3 C5 C1 clopidogrel I639 Cerebral infarction RPS2P55 X-40936652-T-A 1 1 RPS2P55 1 0.0 0.5104148926285744 0 MED repl-underpowered C1 C2 C5 C1 tramadol R101 Pain localized to upper abdomen SCD5 4-82803473-T-C 1 1 SCD5 1 0.0 0.5234815085056919 1 HIGH replicated C1 C1 C4 C1 ramipril I64 Stroke FDX1 FDX1_mpc 1 1 FDX1 2 0.3957324252715818 0.22812358044096676 1 HIGH replicated C2 C4 C3 C1 clopidogrel T828 Complications of cardiac/vascular prosthetic devices HPSE2 10-99237313-A-G 1 1 HPSE2 1 0.0 0.5349310547983256 1 HIGH replicated C1 C3 C5 C1 fluoxetine I48 Atrial fibrillation PCLO 7-82781217-A-C 1 1 PCLO 1 0.0 0.5090260330649364 0 HIGH replicated C1 C1 C4 C1 ramipril I219 Acute myocardial infarction KLF12 13-74048448-C-A 1 1 KLF12 1 0.0014783194187388072 0.4836444803546195 0 LOW unreplicated C1 C1 C4 C1 dextropropoxyphene M796 Pain in limb PLPP3 1-56627480-C-T 1 1 PLPP3 1 0.0 0.29112234748901605 0 HIGH replicated C1 C1 C4 C1 atenolol R002 Palpitations ENSG00000303889 9-136606925-C-T 1 1 ENSG00000303889 1 0.0 0.5577529035129382 1 HIGH replicated C1 C3 C5 C1 amitriptyline R103 Pain localized to other parts of lower abdomen LINC02934 2-65832689-A-G 1 1 LINC02934 1 0.0 0.5454631876172962 1 HIGH replicated C1 C1 C4 C1 simvastatin I251 Atherosclerotic heart disease LPA 6-160589086-A-G 1 1 LPA 33 0.5546141822145201 0.13272457583121755 0 HIGH replicated C3 C5 C1 C1 simvastatin I251 Atherosclerotic heart disease CDKN2B-AS1 9-22072720-A-G 1 3 9-22115027-G-A;9-22116221-C-T;CDKN2B-AS1 16 0.008261752329335018 0.16421480083753404 0 HIGH replicated C3 C5 C1 C1 atenolol I251 Atherosclerotic heart disease 9-22083405-T-C 9-22083405-T-C 1 2 9-22083405-T-C;CDKN2B-AS1 14 0.0 0.18585591350031744 0 HIGH replicated C3 C5 C1 C1 ramipril N189 Chronic kidney disease, unspecified - 13-62873344-A-G 1 1 - 1 0.0 0.5140085377539991 0 HIGH replicated C1 C1 C4 C1 amlodipine I64 Stroke, not specified as haemorrhage or infarction ENSG00000249998 4-17056292-C-T 1 1 ENSG00000249998 1 0.0 0.24852769238036457 1 HIGH replicated C1 C1 C4 C1 atenolol I500 Congestive heart failure - 18-64650136-A-G 1 1 - 1 0.0 0.6017131236788177 1 HIGH replicated C1 C1 C4 C1 tramadol L409 Psoriasis, unspecified HLA-C C_0602_hla 1 1 HLA-C 3 0.3953915992315448 0.22153860352132057 0 HIGH replicated C3 C7 C2 C1 tramadol L409 Psoriasis, unspecified RPL3P2 6-31284147-C-T 1 3 LINC02571;PSORS1C1;RPL3P2 3 0.0 0.22150747795829678 0 HIGH replicated C3 C7 C2 C1 atorvastatin Z955 Presence of coronary angioplasty implant/graft PCDH15 10-55628926-G-T 1 2 ENSG00000236744;PCDH15 1 0.0014783194187388072 0.2781078152187819 0 HIGH replicated C1 C1 C4 C1 simvastatin J90 Pleural effusion OARD1 OARD1_lof 2 1 OARD1 1 0.0 0.5804136460654042 0 HIGH replicated C1 C3 C5 C1 atenolol H609 Otitis externa ANOS1 X-8578630-C-T 2 1 ANOS1 1 0.0 0.5145192280681324 1 HIGH replicated C1 C3 C5 C1 atenolol R739 Hyperglycaemia SLC38A8 16-84041941-C-T 2 1 SLC38A8 1 0.0 0.5202390462710544 1 MED repl-underpowered C1 C3 C4 C1 ramipril M109 Gout, unspecified MATN4 MATN4_lof 2 1 MATN4 1 0.0 0.5424965943289146 1 MED repl-underpowered C1 C2 C5 C1 ramipril M109 Gout, unspecified LINC01376 2-19047295-A-G 2 1 LINC01376 1 0.0 0.6060399864226453 1 HIGH replicated C1 C3 C5 C3 simvastatin R030 Elevated BP reading ACOT12 ACOT12_lof 2 1 ACOT12 1 0.0 0.44937575196736834 1 HIGH replicated C1 C3 C5 C1 ramipril R101 Pain localized to upper abdomen RSU1P1 10-42722542-G-T 2 1 RSU1P1 3 0.0 0.47020057261381465 1 HIGH replicated C1 C3 C5 C1 amlodipine K922 GI haemorrhage GRM7 3-7458237-T-A 2 1 GRM7 1 0.0 0.4788294536342379 1 MED repl-underpowered C1 C2 C4 C1 simvastatin I48 Atrial fibrillation and flutter RASGEF1C RASGEF1C_cnv_gene_down 2 1 RASGEF1C 1 0.0 0.4970196392306118 1 MED repl-underpowered C1 C2 C4 C1 simvastatin M513 Intervertebral disc degeneration MEF2D MEF2D_mpc 2 1 MEF2D 2 0.0022174791281082107 0.5304425274108928 1 HIGH replicated C2 C4 C3 C1 diltiazem M255 Pain in joint SQSTM1 5-179825265-C-A 2 1 SQSTM1 1 0.0073915970936940375 0.4383568076013975 1 MED repl-underpowered C1 C3 C4 C1 simvastatin I517 Cardiomegaly HOXD10 HOXD10_mpc 2 1 HOXD10 2 0.0 0.4902510242805315 1 MED repl-underpowered C2 C4 C3 C1 propranolol R31 Unspecified haematuria LINC01258 4-38455849-C-A 2 1 LINC01258 1 0.0 0.49024143808669507 0 MED repl-underpowered C1 C2 C4 C1 amlodipine R80 Isolated proteinuria LINC02545 11-13850299-A-C 2 1 LINC02545 1 0.0 0.21590903850921922 0 HIGH replicated C1 C6 C5 C1 ramipril G439 Migraine, unspecified CCDC192 5-127900586-T-C 2 1 CCDC192 1 0.0 0.5326516261504189 0 HIGH replicated C1 C3 C5 C1 ramipril G439 Migraine, unspecified DELEC1 9-115342430-T-G 2 2 DELEC1 1 0.0 0.47386779643218363 1 MED repl-underpowered C1 C2 C5 C1 gabapentin E780 Pure hypercholesterolaemia TSPAN8 12-71284188-C-T 2 1 TSPAN8 1 0.0 0.5237407095356773 0 HIGH replicated C1 C1 C4 C1 fluoxetine M549 Dorsalgia GUCY2F X-109371201-A-G 2 1 GUCY2F 1 0.0 0.49311203521971336 0 HIGH replicated C1 C1 C4 C1 fluoxetine M549 Dorsalgia LINC03070 X-5671475-T-C 2 1 LINC03070 1 0.0 0.5099818211972816 1 HIGH replicated C1 C1 C4 C4 ramipril L409 Psoriasis GLP1R 6-39093427-A-G 2 1 GLP1R 1 0.04093571025836034 0.426069459538352 1 MED repl-underpowered C1 C1 C4 C1 ramipril M791 Myalgia LINC00944 12-126690358-C-A 2 4 LINC00944;LINC02824 1 0.0 0.5003503195573974 0 MED repl-underpowered C1 C3 C4 C1 atenolol L409 Psoriasis MICAL3 22-17908089-G-A 2 2 MICAL3 1 0.0 0.4641794236850156 0 HIGH replicated C1 C1 C4 C4 atorvastatin L918 Other hypertrophic disorders of skin - 9-98724864-C-T 2 2 -;GALNT12 1 0.0 0.5125650194462115 1 HIGH replicated C1 C1 C4 C4 atorvastatin L918 Other hypertrophic disorders of skin ENSG00000288098 X-142016244-C-T 2 1 ENSG00000288098 1 0.0 0.5139598263031161 1 HIGH replicated C1 C1 C4 C4 clopidogrel K922 GI haemorrhage OR9Q1 11-58060137-C-T 2 1 OR9Q1 1 0.0 0.6641302065491894 0 HIGH replicated C1 C3 C5 C1 atorvastatin R21 Rash RTN4R 22-20273295-C-T 2 1 RTN4R 1 0.0 0.20643786598062835 1 HIGH replicated C1 C1 C4 C1 bisoprolol R252 Cramp and spasm INTS7 INTS7_mpc 2 1 INTS7 1 0.0 0.48556910081353893 1 HIGH replicated C2 C4 C3 C1 tramadol R31 Unspecified haematuria KCNIP2 10-101828941-G-A 2 1 KCNIP2 1 0.0 0.5451473776177646 1 HIGH replicated C1 C1 C4 C1 clopidogrel M139 Arthritis, unspecified PHEX X-22300612-C-T 2 1 PHEX 1 0.06792253773623753 0.5613523134212287 1 HIGH replicated C1 C1 C4 C4 lisinopril K20 Oesophagitis GNG13 16-804252-G-A 2 1 GNG13 1 0.0 0.5389848979751877 1 HIGH replicated C1 C1 C4 C4 lisinopril R21 Rash MED15 22-20508261-C-T 2 1 MED15 1 0.0 0.1943941193292154 0 MED repl-underpowered C1 C6 C4 C1 tramadol F419 Anxiety disorder - 4-82119215-G-A 2 1 - 1 0.0 0.5287043865329101 1 MED repl-underpowered C1 C2 C4 C2 amlodipine R13 Dysphagia TICAM2 5-115581344-T-C 2 1 TICAM2 1 0.0 0.5230079166451022 1 MED repl-underpowered C1 C1 C4 C1 fluoxetine G560 Carpal tunnel syndrome GFOD1 6-13455966-A-G 2 1 GFOD1 1 0.0 0.5264608194707019 1 MED repl-underpowered C1 C1 C4 C1 ramipril H609 Otitis externa - X-118271931-T-C 2 2 -;WDR44 1 0.0 0.316976680225551 0 HIGH replicated C1 C1 C4 C1 ramipril H609 Otitis externa ENSG00000287566 10-5550285-C-T 2 1 ENSG00000287566 1 0.0 0.28956070217383706 0 MED repl-underpowered C1 C1 C4 C1 temazepam N390 Urinary tract infection SPANXA2-OT1 X-141412320-G-A 2 1 SPANXA2-OT1 1 0.0 0.582479819786922 1 HIGH replicated C1 C3 C5 C1 amlodipine M751 Rotator cuff syndrome PTPN14 1-214349697-G-A 2 1 PTPN14 1 0.0 0.5165814226600748 1 HIGH replicated C1 C1 C4 C4 amlodipine R060 Dyspnoea GRM8 7-127192312-G-A 2 2 GRM8 1 0.0 0.5284204173556387 1 MED repl-underpowered C1 C1 C4 C1 simvastatin G629 Polyneuropathy, unspecified PLB1 2-28457902-C-T 2 1 PLB1 1 0.0 0.5188372337671028 1 HIGH replicated C1 C1 C4 C4 simvastatin I10 Essential (primary) hypertension ENSG00000293732 10-64775221-G-A 2 7 CYP2C61P;ENSG00000293732 1 0.0 0.45167705255875557 1 LOW unreplicated C1 C1 C4 C1 bisoprolol A099 Gastroenteritis - 14-97288492-T-C 2 1 - 1 0.0 0.5761156970322364 1 LOW unreplicated C1 C3 C5 C1 amitriptyline J189 Pneumonia EYS 6-64665130-C-T 2 1 EYS 1 0.2519541707794922 0.5328338934172776 1 MED repl-underpowered C1 C1 C4 C1 furosemide L089 Local skin infection DMD X-31603867-G-A 2 1 DMD 1 0.06420566248887018 0.5058578674082458 1 MED repl-underpowered C1 C1 C4 C1 citalopram K635 Polyp of colon LINC02015 3-177816736-G-A 2 1 LINC02015 1 0.0 0.41928580789573383 0 HIGH replicated C1 C1 C4 C1 simvastatin N328 Other specified disorders of bladder RN7SL278P 15-76974556-T-C 2 1 RN7SL278P 1 0.0 0.4805173733261922 1 HIGH replicated C1 C1 C4 C4 amlodipine J310 Chronic rhinitis chr6:76600001-76700001_cnv_region_down chr6:76600001-76700001_cnv_region_down 2 1 chr6:76600001-76700001_cnv_region_down 1 0.0 0.40023797006944767 1 HIGH replicated C1 C3 C5 C1 amlodipine K589 IBS without diarrhoea AGBL4 1-48632540-T-G 2 1 AGBL4 1 0.0 0.4381936774507685 0 HIGH replicated C1 C1 C4 C1 simvastatin N390 Urinary tract infection DUSP9 DUSP9_mpc 2 1 DUSP9 1 0.0036957985468470188 0.5268527048603654 1 HIGH replicated C2 C4 C3 C1 simvastatin R31 Unspecified haematuria COL4A4 COL4A4_lof 2 1 COL4A4 2 0.0 0.3047239360483198 1 MED repl-underpowered C1 C3 C5 C1 atenolol R252 Cramp and spasm LYL1 LYL1_mpc 2 1 LYL1 3 0.0 0.3670100209439617 1 MED repl-underpowered C2 C4 C3 C1 atorvastatin K589 IBS without diarrhoea LINC01968 3-194777159-C-T 2 1 LINC01968 1 0.0 0.4179799762470109 0 MED repl-underpowered C1 C1 C4 C1 ramipril K589 IBS without diarrhoea ENSG00000301403 14-74395271-G-C 2 1 ENSG00000301403 1 0.0 0.5438052149168566 1 MED repl-underpowered C1 C2 C5 C1 clopidogrel M542 Cervicalgia NR2F1-AS1 5-93360700-G-A 2 1 NR2F1-AS1 1 0.0 0.39938297118303856 0 MED repl-underpowered C1 C1 C4 C1 simvastatin J449 COPD, unspecified CADM2 CADM2_cnv_gene_down 2 1 CADM2 1 0.0 0.5077198329156513 0 HIGH replicated C1 C3 C5 C1 citalopram H612 Impacted cerumen - 11-75024965-T-C 2 1 - 1 0.0 0.4128106958265322 0 HIGH replicated C1 C3 C4 C1 simvastatin I802 Phlebitis and thrombophlebitis deep vessels lower extr. F5 1-169549811-C-T 2 1 F5 8 0.5458235568971362 0.16622002644186631 1 HIGH replicated C3 C7 C2 C1 simvastatin I802 Phlebitis and thrombophlebitis deep vessels lower extr. NME7 1-169191220-C-T 2 1 NME7 7 0.35200224151486503 0.17502712912157806 1 HIGH replicated C3 C7 C2 C1 atorvastatin H409 Glaucoma, unspecified - 4-130925968-C-T 2 1 - 1 0.0 0.4820560725825801 0 HIGH replicated C1 C1 C4 C1 atorvastatin H409 Glaucoma, unspecified - 4-131232615-T-C 2 2 - 1 0.0 0.48470882468735454 0 HIGH replicated C1 C1 C4 C1 atenolol H931 Tinnitus - X-140839067-C-T 2 1 - 1 0.0 0.5608549651869542 1 HIGH replicated C1 C1 C4 C1 bisoprolol L989 Disorder of skin, unspecified ENSG00000302198 20-57987672-A-G 2 1 ENSG00000302198 1 0.0 0.495597624685606 0 HIGH replicated C1 C1 C4 C1 bisoprolol L989 Disorder of skin, unspecified - 2-157159365-C-T 2 1 - 1 0.0 0.5029081859077218 0 HIGH replicated C1 C1 C4 C4 citalopram R074 Chest pain ENSG00000295630 2-122983571-C-T 2 1 ENSG00000295630 1 0.0 0.573880752106349 1 HIGH replicated C1 C1 C4 C1 fluoxetine K20 Oesophagitis - 9-27719841-A-G 2 1 - 1 0.0 0.5526084171504348 0 HIGH replicated C1 C1 C4 C1 losartan L089 Local skin infection - 20-56216436-A-G 2 1 - 1 0.0 0.3952807046613108 0 MED repl-underpowered C1 C1 C4 C1 simvastatin F03 Unspecified dementia - 2-198790131-G-A 2 1 - 1 0.0 0.5444871260749433 0 HIGH replicated C1 C1 C4 C1 simvastatin H000 Hordeolum ENSG00000308003 4-140225948-A-G 2 1 ENSG00000308003 1 0.0 0.39853211128698696 0 HIGH replicated C1 C1 C4 C1 simvastatin Z501 Other physical therapy - 5-29231711-A-G 2 1 - 1 0.0 0.35954532491916524 0 HIGH replicated C1 C1 C4 C1 ramipril K20 Oesophagitis - X-89108942-C-T 2 1 - 1 0.0 0.5166658397925541 1 LOW unreplicated C1 C3 C5 C3 atenolol N920 Excessive menstruation - 4-29761337-A-T 2 2 - 1 0.0 0.3961893756670917 0 MED repl-underpowered C1 C1 C4 C1 citalopram B351 Tinea unguium - 1-116222102-C-T 2 2 - 1 0.0 0.29081721409091293 0 MED repl-underpowered C1 C1 C4 C1 diazepam D649 Anaemia, unspecified - 20-9059027-G-A 2 1 - 1 0.0 0.5780891940849504 0 HIGH replicated C1 C1 C4 C4 bisoprolol R634 Abnormal weight loss ENSG00000242880 3-115339675-G-A 2 1 ENSG00000242880 1 0.0 0.5892986283082231 0 HIGH replicated C1 C1 C4 C1 amlodipine B349 Viral infection, unspecified ENSG00000295272 5-2555671-T-C 2 1 ENSG00000295272 1 0.0 0.3293188279462284 0 MED repl-underpowered C1 C1 C4 C1 atorvastatin F419 Anxiety disorder - 9-68662929-A-G 2 1 - 1 0.0 0.5069445686512865 1 MED repl-underpowered C1 C1 C4 C1 gabapentin A419 Sepsis, unspecified ENSG00000287907 18-68414441-C-T 2 1 ENSG00000287907 1 0.0 0.3507983470456873 0 HIGH replicated C1 C1 C4 C1 tramadol R53 Malaise and fatigue ENSG00000225718 7-69273320-C-T 2 3 ENSG00000225718 1 0.0 0.48267685226326895 0 HIGH replicated C1 C1 C4 C1 citalopram N390 Urinary tract infection - 3-192014844-G-A 2 1 - 1 0.0 0.5367874681315851 1 HIGH replicated C1 C1 C4 C4 citalopram R05 Cough ENSG00000287292 4-148774352-C-T 2 1 ENSG00000287292 1 0.0 0.4484715334870369 1 MED repl-underpowered C1 C1 C4 C1 diazepam M255 Pain in joint ENSG00000282828 2-49605190-T-C 2 1 ENSG00000282828 1 0.0 0.2933495892526565 0 MED repl-underpowered C1 C1 C4 C1 amlodipine N393 Stress incontinence - X-4192675-T-G 2 1 - 1 0.0 0.5225758652448785 0 HIGH replicated C1 C1 C4 C4 atorvastatin M720 Palmar fascial fibromatosis - 12-61170760-T-C 2 1 - 1 0.0 0.2912094482933614 0 HIGH replicated C1 C1 C4 C4 amlodipine R103 Pain localized to other parts of lower abdomen ENSG00000237761 10-104617964-A-G 2 1 ENSG00000237761 1 0.0 0.4737681919784743 1 MED repl-underpowered C1 C1 C4 C1 amitriptyline R21 Rash NETO1-DT 18-72875402-G-A 2 1 NETO1-DT 1 0.0 0.2492409868400923 1 MED repl-underpowered C1 C1 C4 C1